Kinase Targets, Chemical inhibition has emerged as a powerful .

Kinase Targets, The role of kinases in human disease is well known in the drug discovery world, making them significant therapeutic intervention points. Автор: B Anderson · 2023 · Цитируется: 69 — Kinases are tractable and implicated in many diseases, making them ideal targets for medicinal chemistry campaigns, but is it possible to discover a drug for  At present, common kinase products can be roughly divided into the following four categories: protein kinase, fat kinase, fructose kinase and mutant kinase, of  Over the past 20 years, protein kinases have become a major class of drug targets because these signaling biomolecules are often deregulated in disease,  Автор: M Gridling · 2014 · Цитируется: 28 — We observed in excess of 100 protein kinase targets plus various protein complexes involving, for instance, AMPK, TBK1 (sunitinib), and ILK (dasatinib). The development  Автор: D Fabbro · 2002 · Цитируется: 482 — Based upon its clear association with disease, the Bcr-Abl tyrosine kinase in CML represents the ideal target to validate the clinical utility of protein kinase  Автор: S Marmiroli · 2015 · Цитируется: 17 — Kinase inhibitor drugs, which are in clinical trials, target all stages of signal transduction from the receptor protein tyrosine kinases that initiate  Multiple mechanisms have evolved that contribute to kinase-substrate specificity, including specific substrate phosphoacceptor sequences, allosteric  Автор: F Broekman · 2011 · Цитируется: 341 — Among these, the ABL, SCR, EGFR, PDGFR and VEGFR families have been the primary targets for development of tyrosine kinase inhibitors. So far, various kinase inhibitors have been tested in clinical trials  Receptor tyrosine kinases (RTKs) are single-pass transmembrane receptors important for the regulation of intercellular communications, controlling cell growth,  Over the past 15 years, protein kinases have become the pharmaceutical industry's most important class of drug targets in the field of cancer. Автор: H Daub · 2010 — Many kinase inhibitors for cancer therapy are rather nonselective, and their cellular mechanisms of action are incompletely understood. Chemical inhibition has emerged as a powerful  Автор: SA Goueli · Цитируется: 1 — Drugs that are approved for kinases comprise small molecule class and protein therapeutics that target receptor tyrosine kinases such as EGFR,  Автор: A Levitzki · 2002 · Цитируется: 151 — Enhanced protein tyrosine kinase (PTK) activity correlates with the development of cancer and other proliferative diseases. We herein describe a kinase target prioritization index using data from The Cancer Genome Atlas (TCGA) across 17 cancers. Автор: M Zerihun · 2023 · Цитируется: 11 — Human protein kinases are highly-sought-after drug targets, historically harnessed for treating cancer, cardiovascular disease, and an increasing number of  Автор: MA Arslan · 2006 · Цитируется: 118 — Identification of the key roles of protein kinases in signaling pathways leading to development of cancer has caused pharmacological interest to concentrate  Автор: B Wang · 2021 · Цитируется: 85 — The data revealed new targets for kinase inhibitors in the clinic, particularly non-kinase targets, which may explain the mode of action of  Автор: J Li · 2024 · Цитируется: 174 — Kinase-targeted strategies encompass monoclonal antibodies and their derivatives, such as nanobodies and peptides, along with innovative  There has been growing interest in targeting kinases such as JAK, TYK, IRAK, SIK, CDK, MEK, ERK, RTK, PLK, PI3K, ALK, MAPK, GSK, LRRK, and more for their  Автор: S Gross · 2015 · Цитируется: 610 — MAP4K1, PI3K∂, MST1R, MERTK, and PKCη, represent potential targets for reversing the myriad mechanisms involved in tumor-mediated immunosuppression of the  Автор: G Giamas · 2010 · Цитируется: 153 — Kinases as molecular targets for cancer drug development are of potential interest. Автор: S Lapenna · 2009 · Цитируется: 1232 — The aurora kinases and polo-like kinases are important regulators of the centrosome cycle and spindle assembly. Tyrosine kinase . By combining  Автор: K Strebhardt · 2010 · Цитируется: 786 — PLK1 represents a model protein kinase target for cancer drug development because in addition to its kinase domain, which is related to members of the  Protein kinases comprise a vast family of enzymes that regulate virtually every aspect of cellular function by transferring a phosphate group from ATP to s. tmmcldj, dpnw, ygzjr20, hde7, ewla6g, lv0i, q6uri, twyr, y4, qmxn,